• GL183
• MHC class-I specific receptors
• p50.2
• p58.2

MAJOR LINKS FOR CD158b  

• No information

CELLULAR FUNCTION OF CD158b  

• Regulation of NK cell mediated cytolytic activity upon interaction with the appropriate HLA-C alleles

DISEASE RELEVANCE OF CD158b AND FUNCTION OF CD158b IN INTACT ANIMAL   - No information

• Families in which CD158b is a member
  • CD158b-->Killer Inhibitor Receptor
  • CD158b-->p58/p50-->immunoglobulin supergene family

MOLECULAR STRUCTURE OF CD158b  

• Type I glycoproteins belonging to the immunoglobulin superfamily
• Characterized by two extracellular Ig-like domains
• 3 members have been characterized at the molecular level**
• 224 amino acids in extracellular region in all three forms**
• Two ITIM motifs characterize the cytoplasmic tail of the inhibitory (p58.2) form
• Three forms differ in cytoplasmic tail, with either 84, 76, or 39 amino acids respectively**

MOLECULAR MASS OF CD158b  

POST-TRANSCRIPTIONAL MODIFICATION OF CD158b   - No information

POST-TRANSLATIONAL MODIFICATION OF CD158b  

• Several N-linked glycosylation sites**
• Two tyrosine phosphorylation sites in the long cytoplasmic tails only in the inhibitory (p58) form**

SUBSTRATES FOR CD158b   - No information

ENZYMES WHICH MODIFY CD158b   - No information

LIGANDS FOR CD158b AND MOLECULES ASSOCIATED WITH CD158b  

• HLA-Cw3 and related alleles (HLA-Cw1, -Cw7 and -Cw8) and related allotypes displaying
• Ser 77 and Asn 80 | Ligand*
• SHP-1 | Tyrosine phosphatase SHP-1 binds to tyrosine phosphorylated ITIM in the cytoplasmic tail**

• CD158b defines a NK cell subset CD158b may<> also be expressed on rare T cells (either CD3/TCRa/b+ or CD3/TCRg/d+ T lymphocytes)

• This CD includes two different molecules (p58.2 and p50.2) with divergent functional effects (i.e. inhibition and activation, respectively), which are presumably encoded by different genes of the same family**

SELECTION OF OTHER CD158b-SPECIFIC REFERENCE MAB   - No information

REVIEWS

1. Moretta A,Bottino C,Vitale M,Pende D,Biassoni R,Mingari MC,Moretta L Receptors for HLA class-I molecules in human natural killer cells. Annu Rev Immunol 1996 14:619 PubMed

2. NK cells, MHC class I antigens and missing self. Immunological Reviews, Vol.155,1997 (Parham, P. ed., whole volume, 19 articles)

PRIMARY CITATIONS

1. Moretta A,Tambussi G,Bottino C,Tripodi G,Merli A,Ciccone E,Pantaleo G,Moretta L A novel surface antigen expressed by a subset of human CD3- CD16+ natural killer cells. Role in cell activation and regulation of cytolytic function. J Exp Med 1990 171:695 PubMed

2. Ferrini S,Cambiaggi A,Meazza R,Sforzini S,Marciano S,Mingari MC,Moretta L T cell clones expressing the natural killer cell-related p58 receptor molecule display heterogeneity in phenotypic properties and p58 function. Eur J Immunol 1994 24:2294 PubMed

1. Moretta A,Tambussi G,Bottino C,Tripodi G,Merli A,Ciccone E,Pantaleo G,Moretta L A novel surface antigen expressed by a subset of human CD3- CD16+ natural killer cells. Role in cell activation and regulation of cytolytic function. J Exp Med 1990 171:695 PubMed

2. Ferrini S,Cambiaggi A,Meazza R,Sforzini S,Marciano S,Mingari MC,Moretta L T cell clones expressing the natural killer cell-related p58 receptor molecule display heterogeneity in phenotypic properties and p58 function. Eur J Immunol 1994 24:2294 PubMed

WWW RESOURCES

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov